Innate immune memory and homeostasis may be conferred through crosstalk between the TLR3 and TLR7 pathways.

ABSTRACT: Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) and stimulate the innate immune response through the production of cytokines. The innate immune response depends on the timing of encountering PAMPs, suggesting a short-term "memory." In particular, activation of TLR3 appears to prime macrophages for the subsequent activation of TLR7, which leads to synergistically increased production of cytokines. By developing a calibrated mathematical model for the kinetics of TLR3 and TLR7 pathway crosstalk and providing experimental validation, we demonstrated the involvement of the Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) pathway in controlling the synergistic production of cytokines. Signaling through this pathway played a

SUBMITTER: Liu B 

PROVIDER: S-EPMC5087126 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature