Human Cytomegalovirus Infection Enhances NK Cell Activity In Vitro.

ABSTRACT:

Background

Occurring frequently after solid organ and hematopoietic stem cell transplantation, cytomegalovirus (CMV) replication remains a relevant cause of mortality and morbidity in affected patients. Despite these adverse effects, an increased alloreactivity of natural killer (NK) cells after CMV infection has been assumed, but the underlying physiopathological mechanisms have remained elusive.

Methods

We used serial analyses of NK cells before and after CMV infection in kidney transplant recipients as an in vivo model for CMV primary infection to explore the imprint of CMV infection using every patient as their own control: We analyzed NK cell phenotype and function in 47 CMV seronegative recipients of CMV seropositive kidney grafts, who developed CMV primary infection p

SUBMITTER: Tschan-Plessl A 

PROVIDER: S-EPMC5087575 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature