Spatially Compact Neural Clusters in the Dorsal Striatum Encode Locomotion Relevant Information.

ABSTRACT: An influential striatal model postulates that neural activities in the striatal direct and indirect pathways promote and inhibit movement, respectively. Normal behavior requires coordinated activity in the direct pathway to facilitate intended locomotion and indirect pathway to inhibit unwanted locomotion. In this striatal model, neuronal population activity is assumed to encode locomotion relevant information. Here, we propose a novel encoding mechanism for the dorsal striatum. We identified spatially compact neural clusters in both the direct and indirect pathways. Detailed characterization revealed similar cluster organization between the direct and indirect pathways, and cluster activities from both pathways were correlated with mouse locomotion velocities. Using machine-learning algor

SUBMITTER: Barbera G 

PROVIDER: S-EPMC5087607 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature