Calcium Signaling Is Dispensable for Receptor Regulation of Endothelial Barrier Function.

ABSTRACT: Endothelial barrier function is tightly regulated by plasma membrane receptors and is crucial for tissue fluid homeostasis; its dysfunction causes disease, including sepsis and inflammation. The ubiquitous activation of Ca²⁺ signaling upon phospholipase C-coupled receptor ligation leads quite naturally to the assumption that Ca²⁺ signaling is required for receptor-regulated endothelial barrier function. This widespread hypothesis draws analogy from smooth muscle and proposes the requirement of G protein-coupled receptor (GPCR)-generated Ca²⁺ signaling in activating the endothelial contractile apparatus and generating interendothelial gaps. Notwithstanding endothelia being non-excitable in nature, the hypothesis of Ca²⁺-induced endothelial contrac

SUBMITTER: Stolwijk JA 

PROVIDER: S-EPMC5087712 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature