Attention-Deficit/Hyperactivity Disorder symptoms coincide with altered striatal connectivity.

ABSTRACT:

Background

Cortico-striatal network dysfunction in attention-deficit/hyperactivity disorder (ADHD) is generally investigated by comparing functional connectivity of the main striatal sub-regions (i.e., putamen, caudate, and nucleus accumbens) between an ADHD and a control group. However, dimensional analyses based on continuous symptom measures might help to parse the high phenotypic heterogeneity in ADHD. Here, we focus on functional segregation of regions in the striatum and investigate cortico-striatal networks using both categorical and dimensional measures of ADHD.

Methods

We computed whole-brain functional connectivity for six striatal sub-regions that resulted from a novel functional parcellation technique. We compared functional connectivity maps between adolescents

SUBMITTER: Oldehinkel M 

PROVIDER: S-EPMC5087803 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature