Identification of a nutrient-sensing transcriptional network in monocytes by using inbred rat models on a cafeteria diet.

ABSTRACT: Obesity has reached pandemic levels worldwide. The current models of diet-induced obesity in rodents use predominantly high-fat based diets that do not take into account the consumption of variety of highly palatable, energy-dense foods that are prevalent in Western society. We and others have shown that the cafeteria (CAF) diet is a robust and reproducible model of human metabolic syndrome with tissue inflammation in the rat. We have previously shown that inbred rat strains such as Wistar Kyoto (WKY) and Lewis (LEW) show different susceptibilities to CAF diets with distinct metabolic and morphometric profiles. Here, we show a difference in plasma MCP-1 levels and investigate the effect of the CAF diet on peripheral blood monocyte transcriptome, as powerful stress-sensing immune cells, in

SUBMITTER: Martinez-Micaelo N 

PROVIDER: S-EPMC5087837 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature