Modelling Chemotactic Motion of Cells in Biological Tissues.

ABSTRACT: Developmental processes in biology are underlined by proliferation, differentiation and migration of cells. The latter two are interlinked since cellular differentiation is governed by the dynamics of morphogens which, in turn, is affected by the movement of cells. Mutual effects of morphogenetic and cell movement patterns are enhanced when the movement is due to chemotactic response of cells to the morphogens. In this study we introduce a mathematical model to analyse how this interplay can result in a steady movement of cells in a tissue and associated formation of travelling waves in a concentration field of morphogen. Using the model we have identified four chemotactic scenarios for migration of single cell or homogeneous group of cells in a tissue. Such a migration can take place if m

SUBMITTER: Vasiev B 

PROVIDER: S-EPMC5087904 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature