Global Escherichia coli Sequence Type 131 Clade with bla_CTX-M-27 Gene.

ABSTRACT: The Escherichia coli sequence type (ST) 131 C2/H30Rx clade with the bla_CTX-M-15 gene had been most responsible for the global dissemination of extended-spectrum β-lactamase (ESBL)-producing E. coli. ST131 C1/H30R with bla_CTX-M-27 emerged among ESBL-producing E. coli in Japan during the late 2000s. To investigate the possible expansion of a single clade_, we performed whole-genome sequencing for 43 Japan and 10 global ST131 isolates with bla_CTX-M-27 (n = 16), bla_CTX-M-14 (n = 16), bla_CTX-M-15 (n = 13), and others (n = 8). We also included 8 ST131 genomes available in public databases. Core genome-based analysis of 61 isolates showed that ST131 with bla_CTX-M-27 from 5 countries formed a distinct cluster within the C1

SUBMITTER: Matsumura Y 

PROVIDER: S-EPMC5088012 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature