Estimating the ratio of multivariate recurrent event rates with application to a blood transfusion study.

ABSTRACT: In comparative effectiveness studies of multicomponent, sequential interventions like blood product transfusion (plasma, platelets, red blood cells) for trauma and critical care patients, the timing and dynamics of treatment relative to the fragility of a patient's condition is often overlooked and underappreciated. While many hospitals have established massive transfusion protocols to ensure that physiologically optimal combinations of blood products are rapidly available, the period of time required to achieve a specified massive transfusion standard (e.g. a 1:1 or 1:2 ratio of plasma or platelets:red blood cells) has been ignored. To account for the time-varying characteristics of transfusions, we use semiparametric rate models for multivariate recurrent events to estimate blood product

SUBMITTER: Ning J 

PROVIDER: S-EPMC5088066 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature