Correlations of nasal responses to leukotriene D4 and histamine nasal provocation with quality of life in allergic rhinitis.

ABSTRACT:

Background

The symptoms of allergic rhinitis (AR) greatly affect the quality of life (QoL) in the patients with AR. The correlations of nasal response to leukotriene D4 (LTD4) and histamine nasal provocation with health related QoL in AR are not clear.

Objective

To evaluate the correlations of nasal response to LTD4 and histamine nasal challenge with QoL in AR.

Methods

Patients randomly underwent LTD4 and histamine nasal challenge tests, completed the rhinoconjunctivitis quality of life questionnaire (RQoLQ), and rating the symptom severity score (total symptom score 4, TSS4) in the previous week. The correlations between nasal challenge tests induced nasal responses and QoL in RQoLQ were analyzed.

Results

A total of 25 eligible AR patients enrolled and finishe

SUBMITTER: Zhu Z 

PROVIDER: S-EPMC5088261 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature