Halting of Caspase Activity Protects Tau from MC1-Conformational Change and Aggregation.

ABSTRACT: Intracellular neurofibrillary tangles (NFTs) are the hallmark of Alzheimer's disease and other tauopathies in which tau, a microtubule-associated protein, loses its ability to stabilize microtubules. Several post-translational modifications including phosphorylation and truncation increase tau's propensity to aggregate thus forming NFTs; however, the mechanisms underlying tau conformational change and aggregation still remain to be defined. Caspase activation and subsequent proteolytic cleavage of tau is thought to be a potential trigger of this disease-related pathological conformation. The aim of this work was to investigate the link between caspase activation and a disease-related conformational change of tau in a neuroblastoma cell-based model of spontaneous tau aggregation. We demonst

SUBMITTER: Mead E 

PROVIDER: S-EPMC5088409 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature