Ontology highlight
ABSTRACT:
SUBMITTER: Gruner BM
PROVIDER: S-EPMC5088491 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Nature methods 20160912 10
Phenotype-based small-molecule screening is a powerful method to identify molecules that regulate cellular functions. However, such screens are generally performed in vitro under conditions that do not necessarily model complex physiological conditions or disease states. Here, we use molecular cell barcoding to enable direct in vivo phenotypic screening of small-molecule libraries. The multiplexed nature of this approach allows rapid in vivo analysis of hundreds to thousands of compounds. Using ...[more]