Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.

ABSTRACT: Proteins are regulated by an incredible array of posttranslational modifications (PTMs). Methylation of lysine residues on histone proteins is a PTM with well-established roles in regulating chromatin and epigenetic processes. The recent discovery that hundreds and likely thousands of nonhistone proteins are also methylated at lysine has opened a tremendous new area of research. Major cellular pathways involved in cancer, such as growth signaling and the DNA damage response, are regulated by lysine methylation. Although the field has developed quickly in recent years many fundamental questions remain to be addressed. We review the history and molecular functions of lysine methylation. We then discuss the enzymes that catalyze methylation of lysine residues, the enzymes that remove lysine m

SUBMITTER: Carlson SM 

PROVIDER: S-EPMC5088510 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature