Evolutionary hallmarks of the human proteome: chasing the age and coregulation of protein-coding genes.

ABSTRACT:

Background

The development of large-scale technologies for quantitative transcriptomics has enabled comprehensive analysis of the gene expression profiles in complete genomes. RNA-Seq allows the measurement of gene expression levels in a manner far more precise and global than previous methods. Studies using this technology are altering our view about the extent and complexity of the eukaryotic transcriptomes. In this respect, multiple efforts have been done to determine and analyse the gene expression patterns of human cell types in different conditions, either in normal or pathological states. However, until recently, little has been reported about the evolutionary marks present in human protein-coding genes, particularly from the combined perspective of gene expression and prote

SUBMITTER: Lopes KP 

PROVIDER: S-EPMC5088522 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature