Reconstructed cell fate-regulatory programs in stem cells reveal hierarchies and key factors of neurogenesis.

ABSTRACT: Cell lineages, which shape the body architecture and specify cell functions, derive from the integration of a plethora of cell intrinsic and extrinsic signals. These signals trigger a multiplicity of decisions at several levels to modulate the activity of dynamic gene regulatory networks (GRNs), which ensure both general and cell-specific functions within a given lineage, thereby establishing cell fates. Significant knowledge about these events and the involved key drivers comes from homogeneous cell differentiation models. Even a single chemical trigger, such as the morphogen all-trans retinoic acid (RA), can induce the complex network of gene-regulatory decisions that matures a stem/precursor cell to a particular step within a given lineage. Here we have dissected the GRNs involved in th

SUBMITTER: Mendoza-Parra MA 

PROVIDER: S-EPMC5088593 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature