DNA methylation profiles of diverse Brachypodium distachyon align with underlying genetic diversity.

ABSTRACT: DNA methylation, a common modification of genomic DNA, is known to influence the expression of transposable elements as well as some genes. Although commonly viewed as an epigenetic mark, evidence has shown that underlying genetic variation, such as transposable element polymorphisms, often associate with differential DNA methylation states. To investigate the role of DNA methylation variation, transposable element polymorphism, and genomic diversity, whole-genome bisulfite sequencing was performed on genetically diverse lines of the model cereal Brachypodium distachyon Although DNA methylation profiles are broadly similar, thousands of differentially methylated regions are observed between lines. An analysis of novel transposable element indel variation highlighted hundreds of new polymor

SUBMITTER: Eichten SR 

PROVIDER: S-EPMC5088594 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature