Nucleosomal signatures impose nucleosome positioning in coding and noncoding sequences in the genome.

ABSTRACT: In the yeast genome, a large proportion of nucleosomes occupy well-defined and stable positions. While the contribution of chromatin remodelers and DNA binding proteins to maintain this organization is well established, the relevance of the DNA sequence to nucleosome positioning in the genome remains controversial. Through quantitative analysis of nucleosome positioning, we show that sequence changes distort the nucleosomal pattern at the level of individual nucleosomes in three species of Schizosaccharomyces and in Saccharomyces cerevisiae This effect is equally detected in transcribed and nontranscribed regions, suggesting the existence of sequence elements that contribute to positioning. To identify such elements, we incorporated information from nucleosomal signatures into artificial s

SUBMITTER: Gonzalez S 

PROVIDER: S-EPMC5088595 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature