Role of the right dorsal anterior insula in the urge to tic in Tourette syndrome.

ABSTRACT:

Background

The mid-posterior part of the insula is involved in processing bodily sensations and urges and is activated during tic generation in Tourette syndrome. The dorsal anterior part of the insula, however, integrates sensory and emotional information with cognitive valuation and is implicated in interoception. The right dorsal anterior insula also participates in urge suppression in healthy subjects. This study examined the role of the right dorsal anterior insula in the urge to tic in Tourette syndrome.

Methods

Resting-state functional magnetic resonance imaging was performed in 13 adult Tourette patients and 13 matched controls. The role of the right dorsal anterior insula within the urge-tic network was investigated using graph theory-based neural network analysis.

SUBMITTER: Tinaz S 

PROVIDER: S-EPMC5088605 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature