Prenatal paracetamol exposure is associated with shorter anogenital distance in male infants.

ABSTRACT:

Study question

What is the relationship between maternal paracetamol intake during the masculinisation programming window (MPW, 8-14 weeks of gestation) and male infant anogenital distance (AGD), a biomarker for androgen action during the MPW?

Summary answer

Intrauterine paracetamol exposure during 8-14 weeks of gestation is associated with shorter AGD from birth to 24 months of age.

What is already known

The increasing prevalence of male reproductive disorders may reflect environmental influences on foetal testicular development during the MPW. Animal and human xenograft studies have demonstrated that paracetamol reduces foetal testicular testosterone production, consistent with reported epidemiological associations between prenatal paracetamol exposure and cryptorch

SUBMITTER: Fisher BG 

PROVIDER: S-EPMC5088633 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature