Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.

ABSTRACT: Normal brain function depends on the interaction between highly specialized neurons that operate within anatomically and functionally distinct brain regions. Neuronal specification is driven by transcriptional programs that are established during early neuronal development and remain in place in the adult brain. The fidelity of neuronal specification depends on the robustness of the transcriptional program that supports the neuron type-specific gene expression patterns. Here we show that polycomb repressive complex 2 (PRC2), which supports neuron specification during differentiation, contributes to the suppression of a transcriptional program that is detrimental to adult neuron function and survival. We show that PRC2 deficiency in striatal neurons leads to the de-repression of selected, p

SUBMITTER: von Schimmelmann M 

PROVIDER: S-EPMC5088783 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature