Expansion of Signal Transduction Pathways in Fungi by Extensive Genome Duplication.

ABSTRACT: Plants and fungi use light and other signals to regulate development, growth, and metabolism. The fruiting bodies of the fungus Phycomyces blakesleeanus are single cells that react to environmental cues, including light, but the mechanisms are largely unknown [1]. The related fungus Mucor circinelloides is an opportunistic human pathogen that changes its mode of growth upon receipt of signals from the environment to facilitate pathogenesis [2]. Understanding how these organisms respond to environmental cues should provide insights into the mechanisms of sensory perception and signal transduction by a single eukaryotic cell, and their role in pathogenesis. We sequenced the genomes of P. blakesleeanus and M. circinelloides and show that they have been shaped by an extensive genome duplicatio

SUBMITTER: Corrochano LM 

PROVIDER: S-EPMC5089372 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature