Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence.

ABSTRACT:

Objective

To evaluate if cognitive reserve (CR) contributes to interindividual differences in frontal gray matter density (GMD) and executive impairment that underlie heterogeneity in the disease course of confirmed frontotemporal lobar degeneration (FTLD) pathology.

Methods

Fifty-five patients with autopsy confirmation or a pathogenic mutation consistent with underlying tau (FTLD-tau) or TDP-43 (FTLD-TDP) pathology and 90 demographically comparable healthy controls were assessed with T1 MRI and neuropsychological measures (Mini-Mental State Examination, letter fluency, forward digit span, Rey complex figure, and Boston Naming Test). CR was indexed using a composite measure of education and occupation. We used t tests to identify reduced GMD in patients with FTLD relative to

SUBMITTER: Placek K 

PROVIDER: S-EPMC5089523 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature