Evidence of association between sleep quality and APOE ε4 in healthy older adults: A pilot study.

ABSTRACT:

Background

It has been estimated that the prevalence of Alzheimer disease (AD) and related dementias will triple by 2035, unless effective interventions or treatments are found for the neurodegenerative disease. Understanding sleep changes as a marker for both AD risk and progression is a burgeoning area of investigation. Specifically, there is emerging evidence that both sleep disturbances and the APOE ε4 allele are associated with increased dementia risk. Previous research has suggested that in AD, individuals carrying the APOE ε4 allele have decreased sleep quality compared to individuals without the APOE ε4 allele. This observational trial aimed to determine if healthy older adults with the risk allele (APOE ε4+) have more sleep complaints or evidence of objective sleep disrupt

SUBMITTER: Drogos LL 

PROVIDER: S-EPMC5089524 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature