Vitronectin and dermcidin serum levels predict the metastatic progression of AJCC I-II early-stage melanoma.

ABSTRACT: Like many cancers, an early diagnosis of melanoma is fundamental to ensure a good prognosis, although an important proportion of stage I-II patients may still develop metastasis during follow-up. The aim of this work was to discover serum biomarkers in patients diagnosed with primary melanoma that identify those at a high risk of developing metastasis during the follow-up period. Proteomic and mass spectrophotometry analysis was performed on serum obtained from patients who developed metastasis during the first years after surgery for primary tumors and compared with that from patients who remained disease-free for more than 10 years after surgery. Five proteins were selected for validation as prognostic factors in 348 melanoma patients and 100 controls by ELISA: serum amyloid A and cluste

SUBMITTER: Ortega-Martinez I 

PROVIDER: S-EPMC5089559 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature