Epidemiology of lactic acidosis in type 2 diabetes patients with metformin in Japan.

ABSTRACT:

Purpose

To estimate the incidence of lactic acidosis (LA) and role of metformin in Japanese patients with type 2 diabetes mellitus (T2DM) treated with anti-diabetes drugs.

Methods

This retrospective propensity score matched cohort study was conducted using the Japanese Medical Data Vision claims database. T2DM patients aged 18 or above who received diabetes drugs during January 2010 through August 2014 were identified. Cases of LA were identified based on reimbursement codes and confirmed by lactic acid test and subsequent treatment by hemodialysis or intravenous sodium bicarbonate. Poisson regression and Cox proportional hazard models were used to estimate the incidence and assess if metformin use was associated with increased risk of LA.

Results

Thirty cases of LA w

SUBMITTER: Chang CH 

PROVIDER: S-EPMC5089598 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature