Topology, Cross-Frequency, and Same-Frequency Band Interactions Shape the Generation of Phase-Amplitude Coupling in a Neural Mass Model of a Cortical Column.

ABSTRACT: Phase-amplitude coupling (PAC), a type of cross-frequency coupling (CFC) where the phase of a low-frequency rhythm modulates the amplitude of a higher frequency, is becoming an important indicator of information transmission in the brain. However, the neurobiological mechanisms underlying its generation remain undetermined. A realistic, yet tractable computational model of the phenomenon is thus needed. Here we analyze a neural mass model of a cortical column, comprising fourteen neuronal populations distributed across four layers (L2/3, L4, L5 and L6). A control analysis showed that the conditional transfer entropy (cTE) measure is able to correctly estimate the flow of information between neuronal populations. Then, we computed cTE from the phases to the amplitudes of the oscillations ge

SUBMITTER: Sotero RC 

PROVIDER: S-EPMC5089773 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature