Type I interferon suppresses virus-specific B cell responses by modulating CD8⁺ T cell differentiation.

ABSTRACT: Studies have established a role for T cells in resolving persistent viral infections, yet emerging evidence indicates that both T and B cells are required to control some viruses. During persistent infection, a marked lag or failure to generate neutralizing antibodies is commonly observed and likely contributes to an inability to control certain pathogens. Using lymphocytic choriomeningitis virus (LCMV) as a model, we have examined how a persistent viral infection can suppress neutralizing humoral immunity. By tracking the fate of virus-specific B cells in vivo, we report that LCMV-specific B cells were rapidly deleted within a few days of persistent infection, and this deletion was completely reversed by blockade of type I interferon (IFN-I) signaling. Early interference with IFN-I signal

SUBMITTER: Moseman EA 

PROVIDER: S-EPMC5089817 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature