Association of ADIPOQ variants with type 2 diabetes mellitus susceptibility in ethnic Han Chinese from northeast China.

ABSTRACT:

Aims/introduction

To investigate the association between two single nucleotide polymorphisms (SNPs; rs3774261 and rs822393) in the ADIPOQ gene and type 2 diabetes mellitus in Han Chinese from northeast China.

Materials and methods

The present study comprised 993 type 2 diabetes mellitus patients and 966 unrelated controls from northeastern China. Two SNPs were sequenced using SNPscan. The distribution of genotype frequencies of the two SNPs in ADIPOQ between cases and controls, and in subgroups stratified based on body mass index, were compared using logistic regression analysis. Linear regression was used to analyze the association between each SNP and clinical indicators.

Results

The GG genotype of rs3774261 increased the risk of type 2 diabetes mellitus compared wi

SUBMITTER: Yao M 

PROVIDER: S-EPMC5089947 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature