T cell immunoglobulin and mucin domain-containing molecule 3 on CD14⁺ monocytes serves as a novel biological marker for diabetes duration in type 2 diabetes mellitus.

ABSTRACT:

Aims/introduction

Type 2 diabetes is a worldwide disease that is associated with increased rates of obesity and reduced physical activity. Obesity-associated insulin resistance in type 2 diabetes is a disorder in the balance between pro-inflammatory and anti-inflammatory signals. T cell immunoglobulin and mucin domain-containing molecule 3 (Tim-3) has been reported as an important regulatory inflammation molecule, and plays a pivotal role in several inflammation-related diseases.

Materials and methods

Peripheral blood mononuclear cells were obtained from type 2 diabetes patients (n = 31) and healthy donors (n = 18), and Tim-3 expression on peripheral blood mononuclear cells was evaluated by flow cytometry.

Results

We showed the downregulated expression of Tim-3 on CD1

SUBMITTER: Yan WJ 

PROVIDER: S-EPMC5089949 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature