Declining trend in transmitted drug resistance detected in a prospective cohort study of acute HIV infection in Bangkok, Thailand.

ABSTRACT:

Introduction

As availability of antiretroviral therapy expands in developing countries, the risk for transmission of drug-resistant HIV also increases. Patients with acute HIV infection (AHI) provide an opportunity for real-time monitoring of transmitted drug resistance (TDR). SEARCH 010/RV 254 study is a prospective, longitudinal study of AHI. This analysis was performed to characterize changes in TDR over time in persons enrolled in the AHI cohort.

Methods

Genotype testing for TDR mutations was performed on 229 subjects enrolled from 2009 to 2014.

Results

The cohort was predominantly male (95%) and men who have sex with men (92%). TDR prevalence was 7.0%, declining from 12.5% in 2009-2010 to 4.8% in 2013-2014 (p=0.08). By drug class, resistance prevalence was

SUBMITTER: Colby DJ 

PROVIDER: S-EPMC5090107 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature