Ontology highlight
ABSTRACT:
SUBMITTER: Konantz M
PROVIDER: S-EPMC5090218 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Konantz Martina M Alghisi Elisa E Müller Joëlle S JS Lenard Anna A Esain Virginie V Carroll Kelli J KJ Kanz Lothar L North Trista E TE Lengerke Claudia C
The EMBO journal 20160916 21
During development, hematopoietic stem cells (HSCs) emerge from aortic endothelial cells (ECs) through an intermediate stage called hemogenic endothelium by a process known as endothelial-to-hematopoietic transition (EHT). While Notch signaling, including its upstream regulator Vegf, is known to regulate this process, the precise molecular control and temporal specificity of Notch activity remain unclear. Here, we identify the zebrafish transcriptional regulator evi1 as critically required for N ...[more]