Relational Stability of Thyroid Hormones in Euthyroid Subjects and Patients with Autoimmune Thyroid Disease.

ABSTRACT:

Background/aim

Operating far from its equilibrium resting point, the thyroid gland requires stimulation via feedback-controlled pituitary thyrotropin (TSH) secretion to maintain adequate hormone supply. We explored and defined variations in the expression of control mechanisms and physiological responses across the euthyroid reference range.

Methods

We analyzed the relational equilibria between thyroid parameters defining thyroid production and thyroid conversion in a group of 271 thyroid-healthy subjects and 86 untreated patients with thyroid autoimmune disease.

Results

In the euthyroid controls, the FT₃-FT₄ (free triiodothyronine-free thyroxine) ratio was strongly associated with the FT₄-TSH ratio (tau = -0.22, p < 0.001, even after

SUBMITTER: Hoermann R 

PROVIDER: S-EPMC5091265 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature