Altered Striatal Response During Effort-Based Valuation and Motivation in Alcohol-Dependent Individuals.

ABSTRACT:

Aims

To use functional magnetic resonance imaging (fMRI) to investigate the neural circuitry behind effort-related valuation and motivation in a population of alcohol-dependent participants and healthy controls.

Methods

Seventeen alcohol-dependent participants and a comparison group of 17 healthy control participants completed an effort-based motivation paradigm during an fMRI scan, in which they were required to exert effort at varying levels in order to earn a monetary reward.

Results

We found that alcohol-dependent participants were less motivated during trials requiring high levels of effort. The whole-brain fMRI analysis revealed that alcohol-dependent participants displayed an increased blood-oxygen-level dependent (BOLD) signal during low and unknown effort cue

SUBMITTER: Grodin EN 

PROVIDER: S-EPMC5091291 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature