Integrated Electrodes and Electrospray Emitter for Polymer Microfluidic Nanospray-MS Interface.

ABSTRACT: Interfacing of microfluidic devices to mass spectrometry has challenges including dilution from sheath liquid junctions, fragile electrodes, and excessive dead volumes which prevent optimum performance and common use. The goal of this work is to develop a stable nanospray chip-MS interface that contains easily integrated electrodes and an embedded capillary emitter to mitigate current chip-MS problems. This system uses a hybrid polystyrene-poly(dimethylsiloxane) (PS-PDMS) microfluidic platform with an embedded electrode and integrated capillary emitter used as the nanospray interface. Two chip designs were used to evaluate the performance, illustrate on-chip reaction capabilities. By direct infusion, this system showed good performance with LODs of GSH and caffeine of 9 nM and 1 nM, R

SUBMITTER: Forzano AV 

PROVIDER: S-EPMC5091296 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature