Biomarker Profiles in Women with PCOS and PCOS Offspring; A Pilot Study.

ABSTRACT:

Objective

To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring.

Design

Cross-sectional comparison of serum biomarkers.

Setting

University Medical Center Utrecht.

Patients

Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30).

Main outcome measure(s)

Clustering profile of adipocytokines (IL-1b, IL-6, IL-13, IL-17, IL-18, TNF-α, adiponectin, adipsin, leptin, chemerin, resistin, RBP4, DPP-IV/sCD26, CCL2/MCP-1), growth factors (PIGF, VEGF, sVEGF-R1), soluble cell adhesion molecules (sICAM-1/sCD54, sVCAM-1/sCD106), and other inflammatory related proteases (

SUBMITTER: Daan NM 

PROVIDER: S-EPMC5091782 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature