A novel, polymer-coated oncolytic measles virus overcomes immune suppression and induces robust antitumor activity.

ABSTRACT: Although various therapies are available to treat cancers, including surgery, chemotherapy, and radiotherapy, cancer has been the leading cause of death in Japan for the last 30 years, and new therapeutic modalities are urgently needed. As a new modality, there has recently been great interest in oncolytic virotherapy, with measles virus being a candidate virus expected to show strong antitumor effects. The efficacy of virotherapy, however, was strongly limited by the host immune response in previous clinical trials. To enhance and prolong the antitumor activity of virotherapy, we combined the use of two newly developed tools: the genetically engineered measles virus (MV-NPL) and the multilayer virus-coating method of layer-by-layer deposition of ionic polymers. We compared the oncolytic e

SUBMITTER: Nosaki K 

PROVIDER: S-EPMC5091787 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature