Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.

ABSTRACT: Evolutionary differences in gene regulation between humans and lower mammalian experimental systems are incompletely understood, a potential translational obstacle that is challenging to surmount in neurons, where primary tissue availability is poor. Rodent-based studies show that activity-dependent transcriptional programs mediate myriad functions in neuronal development, but the extent of their conservation in human neurons is unknown. We compared activity-dependent transcriptional responses in developing human stem cell-derived cortical neurons with those induced in developing primary- or stem cell-derived mouse cortical neurons. While activity-dependent gene-responsiveness showed little dependence on developmental stage or origin (primary tissue vs. stem cell), notable species-dependen

SUBMITTER: Qiu J 

PROVIDER: S-EPMC5092045 | biostudies-literature | 2016 Oct

REPOSITORIES: biostudies-literature