Tissue remodeling of rat pulmonary arteries in recovery from hypoxic hypertension.

ABSTRACT: The reversibility of tissue remodeling is of general interest to medicine. Pulmonary arterial tissue remodeling during hypertension induced by hypoxic breathing is well known, but little has been said about the recovery of the arterial wall when the blood pressure is lowered again. We hypothesize that tissue recovery is a function of the oxygen concentration, blood pressure, location on the vascular tree, and time. We measured the changes of blood pressure, vessel lumen, vessel wall thicknesses, and opening angle of each segment of the blood vessel at its zero-stress state after step changes of the oxygen concentration in the breathing gas. The zero-stress state of each vessel is emphasized because it is important to the analysis of stress and strain and in morphometry. Experimental result

SUBMITTER: Li Z 

PROVIDER: S-EPMC509227 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature