Rare Variation in TET2 Is Associated with Clinically Relevant Prostate Carcinoma in African Americans.

ABSTRACT:

Background

Common variants have been associated with prostate cancer risk. Unfortunately, few are reproducibly linked to aggressive disease, the phenotype of greatest clinical relevance. One possible explanation is that rare genetic variants underlie a significant proportion of the risk for aggressive disease.

Method

To identify such variants, we performed a two-stage approach using whole-exome sequencing followed by targeted sequencing of 800 genes in 652 aggressive prostate cancer patients and 752 disease-free controls in both African and European Americans. In each population, we tested rare variants for association using two gene-based aggregation tests. We established a study-wide significance threshold of 3.125 × 10^-5 to correct for multiple testing.

Resu

SUBMITTER: Koboldt DC 

PROVIDER: S-EPMC5093030 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature