Remodeling the Vascular Microenvironment of Glioblastoma with α-Particles.

ABSTRACT: Tumors escape antiangiogenic therapy by activation of proangiogenic signaling pathways. Bevacizumab is approved for the treatment of recurrent glioblastoma, but patients inevitably develop resistance to this angiogenic inhibitor. We previously investigated targeted α-particle therapy with ²²⁵Ac-E4G10 as an antivascular approach and showed increased survival and tumor control in a high-grade transgenic orthotopic glioblastoma model. Here, we investigated changes in tumor vascular morphology and functionality caused by ²²⁵Ac-E4G10.

Methods

We investigated remodeling of the tumor microenvironment in transgenic Ntva glioblastoma mice using a therapeutic 7.4-kBq dose of ²²⁵Ac-E4G10. Immunofluorescence and immunohistochemical analyses imaged morphologic ch

SUBMITTER: Behling K 

PROVIDER: S-EPMC5093034 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature