Predicting prolonged dose titration in patients starting warfarin.

ABSTRACT:

Purpose

Patients initiating warfarin therapy generally experience a dose-titration period of weeks to months, during which time they are at higher risk of both thromboembolic and bleeding events. Accurate prediction of prolonged dose titration could help clinicians determine which patients might be better treated by alternative anticoagulants that, while more costly, do not require dose titration.

Methods

A prediction model was derived in a prospective cohort of patients starting warfarin (n = 390), using Cox regression, and validated in an external cohort (n = 663) from a later time period. Prolonged dose titration was defined as a dose-titration period >12 weeks. Predictor variables were selected using a modified best subsets algorithm, using leave-one-out cross-validation

SUBMITTER: Finkelman BS 

PROVIDER: S-EPMC5093054 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature