Recurrent Mutations in the MTOR Regulator RRAGC in Follicular Lymphoma.

ABSTRACT:

Purpose

This study was performed to further our understanding of the biological and genetic basis of follicular lymphoma and to identify potential novel therapy targets.

Experimental design

We analyzed previously generated whole exome sequencing data of 23 follicular lymphoma cases and one transformed follicular lymphoma case and expanded findings to a combined total of 125 follicular lymphoma/3 transformed follicular lymphoma. We modeled the three-dimensional location of RRAGC-associated hotspot mutations. We performed functional studies on novel RRAGC mutants in stable retrovirally transduced HEK293T cells, stable lentivirally transduced lymphoma cell lines, and in Saccharomyces cerevisiae RESULTS: We report recurrent mutations, including multiple amino acid hotspots, in t

SUBMITTER: Ying ZX 

PROVIDER: S-EPMC5093058 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature