Complementary Roles of the Classical and Lectin Complement Pathways in the Defense against Aspergillus fumigatus.

ABSTRACT: Aspergillus fumigatus infections are associated with a high mortality rate for immunocompromised patients. The complement system is considered to be important in protection against this fungus, yet the course of activation is unclear. The aim of this study was to unravel the role of the classical, lectin, and alternative pathways under both immunocompetent and immunocompromised conditions to provide a relevant dual-perspective on the response against A. fumigatus. Conidia (spores) from a clinical isolate of A. fumigatus were combined with various human serum types (including serum deficient of various complement components and serum from umbilical cord blood). We also combined this with inhibitors against C1q, mannose-binding lectin (MBL), and ficolin-2 before compleme

SUBMITTER: Rosbjerg A 

PROVIDER: S-EPMC5093123 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature