Bleeding events and maintenance dose of prasugrel: BLESS pilot study.

ABSTRACT:

Objective

To evaluate changes in residual platelet reactivity (RPR) over time, and bleeding and ischaemic events rate using 5 vs 10 mg maintenance dose (MD) regimens of prasugrel 1 month after acute coronary syndrome (ACS).

Background

The optimal level of RPR with prasugrel may change over time after an ACS.

Methods

After 60 mg loading dose of prasugrel (T0) followed by 10 mg/day for 1 month, patients were randomised to receive prasugrel 10 mg/day (n=95, group A) or 5 mg/day MD (n=98, group B) up to 1 year. RPR was assessed at T0, 37 (T1) and 180 days (T2). The primary end point was Bleeding Academic Research Consortium (BARC) bleeding events ≥2 between 1 and 12 months, and the secondary composite end point was cardiac death, myocardial infarction, stroke and definite

SUBMITTER: Carrabba N 

PROVIDER: S-EPMC5093371 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature