Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word count.

ABSTRACT: Ebolavirus, MERS coronavirus and influenza virus are zoonotic RNA viruses, which mutate very rapidly. Viral growth depends on many host factors, but human cells may not provide the ideal growth conditions for viruses invading from nonhuman hosts. The present time-series analyses of short and long oligonucleotide compositions in these genomes showed directional changes in their composition after invasion from a nonhuman host, which are thought to recur after future invasions. In the recent West Africa Ebola outbreak, directional time-series changes in a wide range of oligonucleotides were observed in common for three geographic areas, and the directional changes were observed also for the recent MERS coronavirus epidemics starting in the Middle East. In addition, common directional changes

SUBMITTER: Wada Y 

PROVIDER: S-EPMC5093548 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature