Fish gut-liver immunity during homeostasis or inflammation revealed by integrative transcriptome and proteome studies.

ABSTRACT: The gut-associated lymphoid tissue, connected with liver via bile and blood, constructs a local immune environment of both defense and tolerance. The gut-liver immunity has been well-studied in mammals, yet in fish remains largely unknown, even though enteritis as well as liver and gallbladder syndrome emerged as a limitation in aquaculture. In this study, we performed integrative bioinformatic analysis for both transcriptomic (gut and liver) and proteomic (intestinal mucus and bile) data, in both healthy and infected tilapias. We found more categories of immune transcripts in gut than liver, as well as more adaptive immune in gut meanwhile more innate in liver. Interestingly reduced differential immune transcripts between gut and liver upon inflammation were also revealed. In addition, mo

SUBMITTER: Wu N 

PROVIDER: S-EPMC5093735 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature