LPA receptor activity is basal specific and coincident with early pregnancy and involution during mammary gland postnatal development.

ABSTRACT: During pregnancy, luminal and basal epithelial cells of the adult mammary gland proliferate and differentiate resulting in remodeling of the adult gland. While pathways that control this process have been characterized in the gland as a whole, the contribution of specific cell subtypes, in particular the basal compartment, remains largely unknown. Basal cells provide structural and contractile support, however they also orchestrate the communication between the stroma and the luminal compartment at all developmental stages. Using RNA-seq, we show that basal cells are extraordinarily transcriptionally dynamic throughout pregnancy when compared to luminal cells. We identified gene expression changes that define specific basal functions acquired during development that led to the identificati

SUBMITTER: Acosta D 

PROVIDER: S-EPMC5093903 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature