Gene expression network analyses in response to air pollution exposures in the trucking industry.

ABSTRACT:

Background

Exposure to air pollution, including traffic-related pollutants, has been associated with a variety of adverse health outcomes, including increased cardiopulmonary morbidity and mortality, and increased lung cancer risk.

Methods

To better understand the cellular responses induced by air pollution exposures, we performed genome-wide gene expression microarray analysis using whole blood RNA sampled at three time-points across the work weeks of 63 non-smoking employees at 10 trucking terminals in the northeastern US. We defined genes and gene networks that were differentially activated in response to PM_2.5 (particulate matter ≤ 2.5 microns in diameter) and elemental carbon (EC) and organic carbon (OC).

Results

Multiple transcripts were strongly asso

SUBMITTER: Chu JH 

PROVIDER: S-EPMC5093980 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature