Discovery and replication of a peripheral tissue DNA methylation biosignature to augment a suicide prediction model.

ABSTRACT:

Background

Suicide is the second leading cause of death among adolescents in the USA, and rates are rising. Methods to identify individuals at risk are essential for implementing prevention strategies, and the development of a biomarker can potentially improve prediction of suicidal behaviors. Prediction of our previously reported SKA2 biomarker for suicide and PTSD is substantially improved by questionnaires assessing perceived stress or anxiety and is therefore reliant on psychological assessment. However, such stress-related states may also leave a biosignature that could equally improve suicide prediction. In genome-wide DNA methylation data, we observed significant overlap between waking cortisol-associated and suicide-associated DNA methylation in blood and the brain,

SUBMITTER: Clive ML 

PROVIDER: S-EPMC5093988 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature