Kidney function, urinalysis abnormalities and correlates in equatorial Africans with sickle cell disease.

ABSTRACT:

Background

Little is known about the renal profiles of individuals with sickle cell disease (SCD) in equatorial Africa, the global epicenter of SCD. We evaluated the kidney function, urinalysis abnormalities and their correlates in a group of Cameroonians homozygous for SCD.

Methods

This was a cross-sectional study of 4-month duration involving 72 homozygous SCD patients (39 men, 54%), recruited during routine visit or vaso-occlusive crisis at the Yaoundé Central Hospital in Cameroon. Clinical and laboratory data were used to evaluate the renal and urinalysis parameters, and potential effects of SCD-related clinical and hematological variables on those parameters investigated through linear and logistic regression models.

Results

The mean serum creatinine increased wi

SUBMITTER: Kaze FF 

PROVIDER: S-EPMC5094388 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature